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Ototoxicity

Did you know that some of the medications you  take may be causing hearing loss? An amazing assortment of common prescription and non-prescription drugs are included. To find out if a particular drug causes hearing loss, enter the drug name and the word "ototoxic" (without the quotes) in your favorite search engine. For example, to determine if aspirin is ototoxic, enter "aspirin ototoxic" (without the quotes.

September 2001 - Doctors at the House Ear Institute are reporting that Vicodin and Similar Painkillers Can Cause Sudden Hearing Loss.

July 2002 - We've been learning a lot about the impact of various drugs on hearing loss, but the information has been scattered and not very accessible. Dr. Neil Baumann's SHHH Convention workshop entitled "Ototoxic Drugs Exposed" does a great job of explaining a complex and often confusing subject.

December 2005 - Chemotherapy can be a wonderful treatment for those suffering from cancer. But it can also cause hearing loss, and the incidence of these occurrences may be underreported!

January 2006 - Platinum cancer drugs tied to hearing loss in kids

February 2006 - Chemo hearing-loss action urged

April 2006 - Aspirin may protect against antibiotic-induced hearing loss

May 2006 - Aspirin Can Prevent Hearing Loss from Ototoxic Medication

September 2006 - St. Jude finds clues to hearing loss from chemotherapy

April 2007 - Test Identifies Early Chemotherapy-Related Hearing Loss

September 2007 - Quark Pharmaceuticals developing drug to prevent hearing loss

October 2007 - FDA warns Viagra tied to hearing loss

October 2007 - Premier Micronutrient Corporation (PMC) Releases Hearing Health Supplement to Address Multiple Conditions

November 2007 - Hearing Loss Preventative in Final Test Phase

November 2007 - Genetic Contribution to Antibiotic Ototoxicity

February 2008 - New Alliance to Combat Hearing Loss

July 2008 - Get a Jump on Ototoxicity

September 2008 - House vs. House: Vicodin Addiction and Hearing Loss

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Platinum cancer drugs tied to hearing loss in kids

January 2006

 

Hearing loss appears to be a significant and under-reported side effect of platinum-based drugs used to treat a variety of childhood cancers, according to researchers. As senior investigator Dr. Edward A. Neuwelt told Reuters Health, so-called "mild" hearing loss "has major impact on academic and social development in kids, is very common after platinum chemotherapy, and may be prevented using" drugs called "thiol oto-protectants" that do not compromise the anti-cancer effects of the chemotherapy. Full Story

 

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Chemo hearing-loss action urged

 

February 2006

 

ISLAMABAD: Drugs companies are being urged to do more to combat hearing loss among cancer patients having chemotherapy. The Royal National Institute for Deaf people (RNID) says thousands are suffering "unnecessary" hearing damage caused by anti-tumour agent cisplatin. It is urging the pharmaceutical industry to develop drugs that block chemotherapy's damaging side-effects. Such drugs have already been identified but the RNID claims that more should be spent on research and development.  Full Story

 

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Aspirin may protect against antibiotic-induced hearing loss

 

A simple dose of aspirin may help protect the hearing of people undergoing treatment with a type of antibiotic commonly used around the world to treat diseases ranging from tuberculosis to cystic fibrosis, report University of Michigan researchers working with colleagues in China. The drugs, known as aminoglycosides, are most often used in developing countries because of their low cost. While they work well against infections, they also carry a high risk for causing hearing loss -- about 8 percent of patients are thought to be affected.  Full Story

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Test Identifies Early Chemotherapy-Related Hearing Loss

April 2007

Among children undergoing platinum-based chemotherapy, early changes in auditory function can be detected using extended high-frequency (EHF) audiometry and evoked distortion product otoacoustic emissions (DPOAEs), according to a report in the April 1st Journal of Clinical Oncology. Platinum chemotherapy is associated with a risk for permanent sensorineural hearing loss in children, the authors explain, but standard monitoring lacks sensitivity in detecting early ototoxicity.  Full  Story

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FDA warns Viagra tied to hearing loss

Impotence drugs will bear new warnings about possible risk

October 2007

Viagra and other impotence drugs are about to bear new warnings that users may experience sudden hearing loss.  It's not clear that the drugs truly trigger hearing loss, but the Food and Drug Administration decided Thursday to add a warning about the possible risk after counting 29 reports of the problem since 1996 among users of this family of medicines.  The impotence drugs Viagra, Cialis and Levitra will bear the warnings. So will Revatio, a drug for pulmonary hypertension, which contains the same ingredient as Viagra.   Full Story

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Hearing Loss Preventative in Final Test Phase

November 2007

Adherex Technologies Inc. has begun the final phase of clinical testing of a treatment developed by Oregon Health & Science University to prevent hearing loss in children undergoing chemotherapy for liver cancer.  Preliminary studies by OHSU scientists suggest that sodium thiosulfate, or STS, can reduce the hearing loss associated with platinum-based chemotherapy. On Tuesday, Adherex said the phase III study will compare the outcomes of children treated with the cancer drug cisplatin alone or in combination with STS.  Full Story

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Genetic Contribution to Antibiotic Ototoxicity

November 2007

In a research article that appeared in the British Medical Journal (BMJ) scientists say they believe patient screening can reduce the risk of hearing loss caused by a genetic mutation that reacts to the use of amnioglycoside antibiotics.At the Institute of Child health, London, England, writers, Maria Bitner-Glindzicz and Shamima Rahman, explain that aminoglycosides are antibiotics that effectively fight serious infections such as complicated urinary tract infections, tuberculosis and septicemia. Use of the medication, however, is known to potentially damage the ear (otoxicity). Researchers are striving to understand the genetic some individuals have to the antibiotic's side effects, which can yield a permanent hearing loss. Families carrying this mutation, even if they never take aminoglycosides, may develop some degree of deafness later in life.   Full Story

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Get a Jump on Ototoxicity

July 2008

Get an early jump on ototoxicity, and you just may preserve a patient's ear function. Ear damage due to the effects of some drugs can be unpredictable and permanent. "The focus is on recognition and prevention of ototoxicity. The earlier you catch it and the more quickly you take the correct action, the better the chances of halting the damage or even recovering function completely," says Susan F. Rudy, RN, MSN, CRNP, CORLN, a research and otolaryngology family nurse practitioner at the National Institute on Deafness and Other Communication Disorders in Bethesda, Md.   Full Story

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House vs. House: Vicodin Addiction and Hearing Loss

September 2008

But now I have discovered that there is another popular "Dr. House," TV's Dr. Gregory House on Fox's "House, M.D." The show's popularity is not to be denied, but I have a very real concern about a message and theme that runs through each episode. It is not his poor bedside manner. It is not his mistreatment of residents. It is his addiction to Vicodin (acetaminophen/ hydrocodone) that is the problem. Here at the House Clinic, my colleagues and I have seen a significant number of patients who have become addicted to Vicodin and have gone completely deaf. They have been taking 15 to 75 tablets per day and in a short period of time have developed a rapidly progressive hearing loss, which leads to permanent total deafness. New research released this week by the Kaiser Family Foundation indicates that people are receiving important health information from prime-time television shows. Although the study looked at the storyline of another medical drama and not "House, M.D.," the important finding is that 45.6 percent of the audience surveyed remembered the key medical information six weeks later.   Full Story