UAMS Study Shows Potential to Greatly Diminish Ringing
in the Ears
Editor: The conventional wisdom that there is no cure for tinnitus may
be changing! We've seen recent positive results with several techniques,
and now the folks at the University of Arkansas are reporting good success
with low-frequency repetitive transcranial magnetic stimulation (TMS).
A study conducted at the University of Arkansas for Medical Sciences (UAMS)
has shown potential to markedly improve tinnitus, commonly known as
"ringing in the ears."
Mark Mennemeier, Ph.D., and John Dornhoffer, M.D., worked
collaboratively to design the treatment study. Results of the initial case
were published in the July issue of The Laryngoscope in which a single
patient was tested to examine the safety and feasibility of using
maintenance sessions of low-frequency repetitive transcranial magnetic
stimulation (TMS) to reduce tinnitus loudness and prevent its return over
To read the study, visit http://www.uams.edu/neuroscience_cellbiology/faculty/tinnitus.pdf.
Mennemeier is associate professor of neurobiology and director of the
Transcranial Magnetic Stimulation Laboratory in the Center for
Translational Neuroscience (CTN) at UAMS. He conducts the treatment study
and evaluates its effectiveness.
Dornhoffer is professor of otology/neurotology at UAMS and a
clinician/scientist in the CTN. He evaluates patients for entry into the
study and holds a grant from the Tinnitus Research Consortium that funds
Tinnitus is defined as the perception of sound in the absence of
external sound and can manifest itself in variety of ways.
"The phantom sounds of tinnitus may sound like ringing, clicking or
hissing," Mennemeier said. "The sounds can change with the time of day and
often cause sleep problems and emotional distress." Tinnitus affects about
17 percent of Americans, often without an observable cause.
TMS involves the placement of a coil on the scalp that creates a
magnetic field over the brain's surface. The magnetic field penetrates up
to two or three centimeters from the surface of the coil. An electric
current is induced by the magnetic field that either activates or inhibits
The goal of the study is to inhibit excessive neural activity believed
to cause tinnitus. "We use a PET scan of the patient's brain to look for
excessive neural activity with increased blood flow in the temporal lobe.
Then we target that area with low-frequency TMS to inhibit the neural
activity and decrease the tinnitus," Mennemeier said.
While TMS has previously shown short-term effectiveness in European
studies, the UAMS team was the first to introduce it as maintenance
therapy in which patients receive an initial course of treatment and
follow-ups as symptoms persist.
The case study of one UAMS patient demonstrated for the first time the
feasibility of managing chronic tinnitus through maintenance TMS. "The
patient in our case study reported his tinnitus to be unobtrusive in his
daily life when he was assessed four months after his final round of
maintenance therapy," Mennemeier said. No side effects were reported by
the patient or detected in formal assessments after three rounds of
UAMS is the state's only comprehensive academic health center, with
five colleges, a graduate school, a medical center, six centers of
excellence and a statewide network of regional centers. UAMS has 2,538
students and 733 medical residents. Its centers of excellence include the
Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine &
Neurosciences Institute, the Myeloma Institute for Research and Therapy,
the Harvey & Bernice Jones Eye Institute, the Psychiatric Research
Institute and the Donald W. Reynolds Institute on Aging. It is one of the
state's largest public employers with about 9,600 employees, including
nearly 1,150 physicians who provide medical care to patients at UAMS,
Arkansas Children's Hospital, the VA Medical Center and UAMS' Area Health
Education Centers throughout the state. UAMS and its affiliates have an
economic impact in Arkansas of $5 billion a year. Visit www.uams.edu.