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Last Update: July 20

 

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Drugs that Cure Hearing Loss

Several efforts are underway to develop drugs that can prevent or treat various types of hearing loss. We've been following some of these efforts rather closely and will continue to bring you news of these efforts as it becomes available.

American BioHealth

Auris Medical

Sound Pharmaceuticals

Here are additional stories about drugs that may cure or prevent hearing loss:

March 2007 - Anti-epileptic drugs may help prevent and treat noise-induced hearing loss

March 2007 - Genetic hearing loss may be reversible without gene therapy

April 2007 - Antioxidants: An Antidote for Noise-Induced Hearing Loss?

June 2007 - Evidence lacking to guide treatment for sudden hearing loss

September 2007 - Quark Pharmaceuticals developing drug to prevent hearing loss

October 2007 - Premier Micronutrient Corporation (PMC) Releases Hearing Health Supplement to Address Multiple Conditions

Mar 2008 - Hearing Pill to Undergo More Clinical Trials

June 2008 - Chemical Combo May Prevent Hearing Loss

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Quark Pharmaceuticals developing drug to prevent hearing loss

September 2007

Quark Pharmaceuticals Inc, a clinical-stage biopharmaceutical company focused on discovering and developing novel RNA interference-based therapeutics, announced today that it has expanded its relationship with the State University of New York at Buffalo, Center for Hearing & Deafness, which is the company's primary site for the pre-clinical studies of its product candidate, AHLi-11, for the treatment of acute hearing loss. Quark initiated its collaboration with the State University of New York in 2005. The current studies, led by Richard Salvi, PhD, focus on the in-depth analysis of the effect of AHLi-11 and other molecules in preventing chemotherapy-induced hearing loss. Based on these studies, Quark Pharmaceuticals expects to file an IND within 2007 for AHLi-11 for the prevention chemotherapy-induced hearing loss. AHLi-11 is a siRNA-based drug that temporarily inhibits the expression of human gene p53. Cochlear hair cell apoptosis (cell death), a key factor in several of the more common causes of acute hearing loss, is believed to be induced by molecular mechanisms most likely associated with p53-dependent stress response. Inhibition of p53, therefore, is suggested as a potential modality for the prevention of ototoxic hearing loss, a common side-effect of certain drugs including aminoglycoside antibiotics and cancer therapeutics such as cisplatin, as well as acoustic trauma.  Full Story