Cochlear Implant Work at UW
Editor: Here's a brief introduction to what's going on in the CI world
at the Virginia Merrill Bloedel Hearing Research Center at the University
of Washington. This article first appeared in their online newsletter at
http://depts.washington.edu/hearing/pdf/bloedelsound.pdf
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The cochlear implant is a device allowing the deaf to hear. The
cochlear implant was developed initially in the 1960's and 1970's. The FDA
approved the device and it became widely available in the mid 1980's.
Today, more than 100,000 people world-wide use a cochlear implant. Early
devices delivered electrical charge to the auditory nerve via electrodes
implanted in the inner ear. Research and development has lead to numerous
advances in the device, such as the use of more electrodes and
"interleaved", non-simultaneous electrical pulses, have improved the
ability of users to resolve the acoustic spectrum of high vs. low
frequencies. These advances have enabled the implant to become one of the
most remarkable biomedical devices available. The risks of use are minimal
and benefits are enormous. Implant users who have lost their hearing in
adulthood, or children who received an implant at an early age, have been
highly successful users. These patients, who formerly received no benefit
from a hearing aid, can usually understand speech well and often can
converse on the telephone. While the cochlear implant has been a huge
success, the device has some shortcomings. Namely, patients often complain
they have great difficulty understanding speech in noisy environments, and
they complain that music sounds terrible. Implant users, for example, have
great difficulty hearing melodies or picking out individual instruments or
voices in a musical group.
At the Virginia Merrill Bloedel Hearing Research Center (VMBHRC), we
are engaged in research to improve the cochlear implant. Dr. Jay T.
Rubinstein, Director of the Center, has invented an approach for improving
hearing with a cochlear implant. The approach, referred to as
"conditioning", conditions the nerves with low-level electrical pulses,
making the auditory nerves more ready to respond. Spontaneous nerve
activity is present in normal-hearing people, but not in the deaf. The
nerves lie mostly dormant. Conditioning introduces low-level electrical
pulses to stimulate spontaneous activity and make the auditory nerves more
alive. The approach helps the implant create nerve impulses that are more
like normal nerve impulses than the nerve impulses created by previous
technology.
Dr. Rubinstein's conditioning technology and has only been implemented
at three laboratories around the world, under his direction. Two implants
also can increase the chances that the user will understand speech,
because they are two implants provides more information. For example if
some frequency range does not respond on one side, it might respond on the
other or both. Having more information can only help their hearing. The
combination of conditioning and two implants has, to date, proven hugely
beneficial in the one user who has received this treatment at Bloedel. Her
speech understanding has improved about 30 percentage points since she had
one implant without the conditioning. Work in this area continues as more
patients receive conditioning, a second implant or both.
Additional cochlear implant research is described in the attached
article from the Seattle Post- Intelligencer. University of Washington
Medical Center is part of a multicenter clinical trial of hybrid cochlear
implant technology developed at the University of Iowa by VMBHRC board
member, Dr. Bruce Gantz. The hybrid cochlear implant can be inserted into
the cochlea without destroying cochlear hair cells, an unfortunate
side-effect of standard cochlear implants. This allows implantation of
hybrid devices into people with far more hearing than is allowable with
standard implants. Part of what makes this such a promising technology and
an exciting project for the Center is that it may provide synergy between
the Hearing Regeneration Initiative and our implant research. Because
regenerating hair cells is less complex than regenerating an entire
cochlea, it seems likely that the first application of hair cell
regeneration in humans will be to augment the efficacy of cochlear
implants. Such implants will probably incorporate hybrid technology and
surgical procedures. With its expertise in these core areas, the Virginia
Merrill Bloedel Hearing Research Center is uniquely positioned to push the
boundary of treatments for hearing loss today and into the future.